CLINICAL AND ETIOLOGICAL PROFILE OF EPILEPSY WITH ONSET WITHIN THE FIRST 3 YEARS OF LIFE IN A TERTIARY CARE HOSPITAL

Abstract



Context
Epilepsy, a common neurological disorder, affects nearly 50 million people worldwide with 1% disease burden and causes 1.32 million years of life loss. A very few studies are available from India describing the clinical and etiological profile of epilepsy in Tamilnadu.
Aims
To study the clinical and etiological profile of early onset (first 3 years of life) epilepsy in tertiary care hospital. Settings and Design: Observational study
Methods and Material:
All epileptic patients who met inclusion criteria were approached and various demographic parameters were noted. All patients underwent 1.5 tesla MRI brain imaging for etiology identification.
Statistical analysis:
Chi-Square test and independent ‘t’ test were applied for comparison of proportions and means respectively. P value <0.05 was considered as significant.
Results:
A total of 115 patients were included in the study. Sex of the patient did not affect the seizure prognosis. Perinatal encephaloclastic conditions (included hypoxic ischemic encephalopathy, neonatal hypoglycaemic injuries, periventricular leucomalacia, and focal infarcts) were found in 50 (43.5%) patients whereas only 11(9.5%) patients had other etiology. Delayed cry at birth (p<0.001), new born admission, low birth weight, delayed initiation of new born feeding are the significant risk factors for perinatal encephaloclastic conditions (p<0.001).
Conclusion:
Our study establishes contribution of perinatal encephaloclastic conditions particularly hypoxic hypoglycaemic injuries as an important cause of early childhood onset epilepsies. Hence quality perinatal care may be the need of the hour to prevent early onset childhood epilepsy in a large group of patients.

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